Boosting Youthful Vitality: NAD+ Infusions for Anti-Aging
Introduction
Aging isn’t just about fine lines or wrinkles—at the cellular level, it means declining repair, diminished energy production, and accumulating damage. Recent research highlights that levels of Nicotinamide Adenine Dinucleotide (NAD+) decline as we age, and this decline may accelerate aging-related changes. 1, 2 At River to Sea Wellness, our NAD+ Infusion Therapy is designed to deliver high-potency NAD+ directly into the bloodstream, supporting cellular metabolism, DNA repair, skin renewal, and overall vitality.
What is NAD+ & Why It Matters
NAD+ is a vital coenzyme present in every cell. It functions in redox (electron-transfer) reactions, supports mitochondrial energy production, and is a substrate for key longevity enzymes such as sirtuins and PARPs (Poly-ADP-Ribose Polymerases). 1, 2
As we age, NAD+ levels drop, which may reduce mitochondrial function, weaken DNA repair, and accelerate the hallmarks of aging (e.g., cellular senescence, genomic instability, impaired proteostasis). 4
Because of this, therapies that restore NAD+ levels—including infusions—are gaining interest in the wellness and aesthetic industries.
Proven & Promising Benefits of NAD+ Infusion Therapy
Here are key areas where NAD+ infusions may help support anti-aging goals:
Enhanced Cellular Energy & Mitochondrial Function By replenishing NAD+, which is essential for mitochondrial ATP production, cells can operate more efficiently—helping tissues like skin, muscle, and organs maintain vitality. 6
Improved DNA Repair & Genomic Stability NAD+ is required for activation of PARPs and sirtuins, enzymes that help repair DNA damage and regulate gene expression—critical processes in slowing cellular aging. 1
Skin Health and Anti-Aging Effects A recent in-vitro study found that exogenous NAD+ improved fibroblast resilience (skin cell function) and boosted markers of mitochondrial health and autophagy—two key factors in skin aging. 3
Support for Age-Related Organ Systems Declining NAD+ levels have been linked to cardiovascular, metabolic, and neurodegenerative aging. Elevating NAD+ may help maintain healthier organ systems as we age. 7
Potential to Slow the Aging Trajectory Reviews suggest that NAD+ boosting is a promising strategy to slow down age-related decline—though human clinical data are still emerging. 4, 6
How the NAD+ Infusion Works at River to Sea Wellness
Our anti-aging NAD+ infusion is designed for maximal bioavailability and safety. Here’s what to expect:
A pre-infusion consultation and baseline labs if needed.
Intravenous delivery of NAD+ (and potentially supporting nutrients such as antioxidants or co-factors) over 30-60 minutes.
Post-infusion hydration and light activity restriction for optimal uptake.
Regular follow-up infusions may be recommended (frequency varies per individual).
Combined with healthy lifestyle practices (nutrition, sleep, skin care) for best results.
What the Research Says: Evidence & Limitations
While the science is promising, it's important to maintain realistic expectations.
A comprehensive review concluded that while raising NAD+ is a promising therapeutic strategy in aging, large-scale human trials remain limited. 4
Another article notes that many NAD+ therapies are still investigated in animal models and small human studies; robust evidence for reversing aging or extending lifespan in humans is not yet available. 8
Practical considerations: dose standardization, long-term safety, cost, and individual responsiveness remain under investigation.
Why Choose River to Sea Wellness for Your NAD+ Therapy
At River to Sea Wellness, we combine clinical-grade IV therapy, personalized assessments, and holistic wellness support. Our goal: to help you feel revitalized, age with strength and grace, and support skin and body from the inside out.
Conclusion
NAD+ infusions represent a frontier in anti-aging wellness—by supporting fundamental cellular processes like energy production, DNA repair, and mitochondrial health. While the research is still evolving, early results are compelling. If you’re interested in exploring how NAD+ therapy can fit into your wellness roadmap, we’re here to guide you. Book your consultation today and begin your journey to thriving at every age.
References
Conlon N.J., et al. The Role of NAD+ in Regenerative Medicine. PMC, 2021. PMC
Radenkovic D., et al. Clinical Evidence for Targeting NAD Therapeutically. PMC, 2020. PMC
Kang S., et al. Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous NAD+. Cells, 2024. MDPI
Braidy N., Liu Y. NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis. Exp Gerontol, 2020. PubMed
Iqbal T., et al. The therapeutic perspective of NAD+ precursors in age-related decline. Biochemical Journal, 2024. ScienceDirect
Aman, Y., Qiu, Y., Tao, J. & Fang, E. F. (2018). Therapeutic potential of boosting NAD⁺ in aging and age-related diseases. Translational Medicine of Aging, 2(6), 30 – 37. https://doi.org/10.1016/j.tma.2018.08.003
Abdellatif, M., Sedej, S., Kroemer, G., et al. (2021). NAD⁺ metabolism in cardiac health, aging, and disease. Circulation, 144 (22), 1795–1817. https://doi.org/10.1161/CIRCULATIONAHA.121.056589
Handzel, S. (2022, October 7). Is NAD therapy all it’s cracked up to be? Here’s the evidence. MDLinx. https://www.mdlinx.com/article/is-nad-therapy-all-its-cracked-up-to-be-heres-the-evidence/4nto35HwTjVcM6Y9J3anaF